Mahshid Meysami, Mohammad Hashem Hashempur, Mohammad Kamalinejad and Majid Emtiazy* Pages 1 - 6 ( 6 )
Background: Atopic dermatitis (AD) is a chronic inflammatory pruritic dermatologic disease in children. Malva sylvestris L. (M. sylvestris) is a medicinal plant which is used as a remedy for eczema in traditional Persian medicine. Previous studies have shown anti‐ulcerogenic and anti‐inflammatory activity of this plant.
Objectives: We designed a clinical trial to evaluate efficacy of topical cream of M. sylvestris extract in management of children with AD.
Methods: Fifty one children with AD were randomly enrolled in two arms of a randomized, double-blind, controlled clinical trial. They were treated by topical cream of M. sylvestris extract or placebo for a palm-sized surface (single fingertip unit, twice daily) for 4 weeks. The SCORing Atopic Dermatitis (SCORAD) score was set as the primary outcome measure.
Results: There was a significant improvement in the severity of participants’ dermatitis regarding skin thickening score, redness score, and total SCORAD score of the M. sylvestris group as compared with the placebo group (P= 0.009, P=0.01, and P=0.03; respectively).
Conclusion: According to the results of this clinical trial, it could be concluded that topical use of M. sylvestris extract cream was effective on the reduction of the AD symptoms in children.
Malva sylvestris L., atopic dermatitis, complementary medicine, traditional Persian medicine, herbal medicine, integrative medicine
Department of Persian Medicine, The School of Persian Medicine, Shahid Sadoughi University of Medical Sciences, Ardakan, Yazd, Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Research Center for Iranian Traditional Medicine, Shahid Sadoughi University of Medical Sciences, Yazd