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Negative Correlation between Neuregulin-4 and IL-9 Serum Levels in Patients with Coronary Artery Disease

Author(s):

Hossein Farshidi, Nadereh Naderi, Hossein Montazerghaem, Narges Farshidi and Mahsa Rahimzadeh*   Pages 1 - 7 ( 7 )

Abstract:


Background: Neuregulin 4 (Nrg4) is a novel adipocytokine which has been proposed to play a role in modulating energy metabolism and pathogeneses of atherosclerosis. However, no published research is available about the mechanisms underlying the anti-atherosclerotic effect of Nrg4. Regarding the close link between adipocytokines and immune system, we wonder whether there is a relation between Nrg4 and athero-protective cytokines. The aim of this study was to investigate the relationship between serum Nrg4 levels and type 2 cytokines in Iranian patients with coronary artery disease (CAD).

Methods: In this case-control study, 125 CAD patients were compared to 55 healthy controls. Serum concentration of Nrg4, IL-5, IL-9 and IL-13 were measured using ELISA. The associations of circulating Nrg4 and IL-5, IL-9, IL-13 were assessed using linear regression analyses.

Results: Serum concentration of IL-9 was significantly higher in patients compared to the healthy controls (317.9±139 versus 228.3±99.1, P= ˂0.0001). IL-13 and Nrg4 were significantly lower in patients compared to the healthy controls (4.3±3.7 versus 6.1±3.9, P=0.01 and 0.5 versus 1.3, P=0.001 respectively). Multiple linear regression analyses revealed that IL-9 was negatively correlated with Nrg4 (β= -0.3, P=0.009).

Conclusion: Our study ،for the first-time, provides the clinical evidence revealing that circulating Nrg4 concentrations are inversely correlated with IL-9 in Iranian patients with CAD, suggesting that the protective role of Nrg4 on atherosclerosis may be, in part, mediated by the proatherogenic cytokine, IL-9.

Keywords:

Coronary artery disease, IL-9, IL-5, IL-13, Neuregulin-4, case-control study.

Affiliation:

Cardiovascular Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Department of Immunology, Faculty of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Cardiovascular Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Department of Immunology, Faculty of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Department of Biochemistry, Faculty of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas



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