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Contribution of Rs780094 and Rs1260326 Polymorphisms in GCKR Gene to Non-alcoholic Fatty Liver Disease: A Meta-Analysis Involving 26,552 Participants

Author(s):

Jiaying Li, Yuening Zhao, Hongxiang Zhang, Wenxi Hua, Wenzhi Jiao, Xuan Du, Jingwen Rui, Si Li, Haiying Teng, Bimin Shi, Xiaoqin Yang* and Liyan Zhu   Pages 1 - 13 ( 13 )

Abstract:


Background: Many published studies attempted to elucidate the implication of glucokinase regulator gene (GCKR) polymorphisms in the susceptibility to nonalcoholic fatty liver disease (NAFLD), but the results among them were still with controversy.

Objective: This meta-analysis aims to precisely assess the relationship between the GCKR polymorphisms and the risk of NAFLD.

Methods: Systematic computerized searches in six databases were performed and updated to April 6, 2020. Meta-analyses were conducted by calling the R programs based on accumulated epidemiological data. Odds ratio (OR) and 95% confidential interval (CI) were calculated to summarize the effect estimates.

Results: In total, 25 studies involving 6,598 cases and 19,954 controls were included. The pooled estimates indicated that the T allele carrier of the GCKR rs780094 polymorphism has predisposition to NAFLD (allele model: OR: 1.20, 95% CI: 1.11~1.29; homozygote model: OR: 1.38, 95% CI: 1.15~1.67; heterozygote model: OR: 1.25, 95% CI: 1.12~1.39; dominant model: OR: 1.29, 95% CI: 1.13~1.47; recessive model: OR: 1.18, 95% CI: 1.06~1.31), and the same as the rs1260326 polymorphism (allele model: OR: 1.32, 95% CI: 1.22~1.42; homozygote model: OR: 1.65, 95% CI: 1.40~1.94; heterozygote model: OR: 1.24, 95% CI: 1.07~1.43; dominant model: OR: 1.39, 95% CI: 1.21~1.59; recessive model: OR: 1.44, 95% CI: 1.28~1.62). Further stratified analyses according to age and ethnicity confirmed the statistical existence in most subgroups.

Conclusion: This meta-analysis suggested that both of the GCKR rs780094 and rs1260326 polymorphisms are significantly associated with the increased risk of NAFLD.

Keywords:

Nonalcoholic fatty liver disease, glucokinase regulator gene, rs780094, rs1260326, meta-analysis, susceptibility.

Affiliation:

Center for Systems Biology, Department of Bioinformatics, School of Biology and Basic Medical Sciences, Soochow University, Suzhou 215123,, Medical College, Soochow University, Suzhou 215123,, Medical College, Soochow University, Suzhou 215123,, Medical College, Soochow University, Suzhou 215123,, Medical College, Soochow University, Suzhou 215123,, Department of Endocrinology and Metabolism, the First Affiliated Hospital of Soochow University, Suzhou 215006,, Medical College, Soochow University, Suzhou 215123,, Medical College, Soochow University, Suzhou 215123,, Medical College, Soochow University, Suzhou 215123,, Department of Endocrinology and Metabolism, the First Affiliated Hospital of Soochow University, Suzhou 215006,, Center for Systems Biology, Department of Bioinformatics, School of Biology and Basic Medical Sciences, Soochow University, Suzhou 215123,, Experimental Center of Medical College, Soochow University, 199 Ren'ai Road, Suzhou 215123, Jiangsu



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