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UCP2 and CFH Gene Variants with Genetic Susceptibility to Schizophrenia in Turkish Population

Author(s):

Ayse Feyda Nursal*, Pinar Cetinay Aydin, Mustafa Pehlivan, Ulgen Sever and Sacide Pehlivan   Pages 1 - 6 ( 6 )

Abstract:


Objective: Schizophrenia (Sch) is a complex, multifactorial psychiatric disorder. Growing evidence shows that oxidative damage and immunological dysfunction exist in the Sch physiopathology. In the present study, we aimed to evaluate whether the Uncoupling protein 2 and Complement factor H gene variants play any role in susceptibility to Sch.

Methods: This study was carried out on 200 individuals (100 Sch patients and 100 healthy controls). Genomic DNA was extracted from blood samples.UCP2-866G /A (rs659366) and CFHY402H variants were analyzed by PCR-RFLP analysis.

Results: The UCP2 -866G/A variant G/G genotype and G allele were associated significantly with increased risk of Sch (p=0.001, p=0.001, respectively). The subjects carrying UCP2 -866G/A variant G/G genotype had 4.377-fold increased risk for Sch.There was no significant difference between the groups for the genotype and allele frequencies of CFH Y402H variant (p>0.05). The observed genotype counts deviated significantly from those expected in Sch patients according to the HWE for UCP2 -866G/A variant (p=0.001).

Conclusion: We present the first results investigating UCP2 -866G/A/ and CFH Y402H variants for susceptibility to Sch in a Turkish population. These results indicate that the UCP2 -866G/A, but not CFH Y402H variant, might play an important role in the development of Sch.

Keywords:

Schizophrenia, uncoupling protein 2, complement factor H, variant, Turkish population.

Affiliation:

Department of Medical Genetics, Faculty of Medicine, Hitit University, Çorum, Department of Psychiatry, Bakirkoy Mental Health Research and Training Hospital, Istanbul, Department of Hematology, Faculty of Medicine, Gaziantep University, Gaziantep, Department of Medical Biology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Department of Medical Biology, Istanbul Faculty of Medicine, Istanbul University, Istanbul



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