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Berberine in the Treatment of Diabetes Mellitus: A Review

[ Vol. 21 , Issue. 8 ]

Author(s):

Aleksandra Baska*, Kamil Leis and Przemysław Gałązka   Pages 1379 - 1386 ( 8 )

Abstract:


Berberine is an alkaloid found in plants. It has neuroprotective, anti-inflammatory and hypolipidemic activities. The research proves that it also strongly impacts carbohydrate metabolism. The compound also protects pancreatic β-cells and increases sensitivity to insulin in peripheral tissues via the induction of GLUT-1, GLUT-4 and insulin type 1 (Ins-1) receptors activity. It also stimulates glycolysis and leads to a decrease in insulin resistance by macrophages polarization, lipolytic processes induction and energy expenditure enhancement (by reducing body mass and limiting insulin resistance caused by obesity). In liver berberine inhibits FOX01, SREBP1 and ChREBP pathways, and HNF-4α (hepatocyte nuclear factor 4 alpha) mRNA that hinder gluconeogenesis processes. In the intestines it blocks α-glucosidase contributing to glucose absorption decrease. Its interference in intestinal flora reduces levels of monosaccharides and suppresses diabetes mellitus complications development.

Keywords:

Berberine, alkaloid, diabetes mellitus, metabolism, nutrition, review.

Affiliation:

Faculty of Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, ul. Jagiellońska 13/15, 85-090Bydgoszcz, Faculty of Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, ul. Jagiellońska 13/15, 85-090Bydgoszcz, Department of General and Oncological Pediatric Surgery, Antoni Jurasz University Hospital No. 1 in Bydgoszcz, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, ul. Marii Skłodowskiej- Curie 9, 85-094Bydgoszcz



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