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An Intimate Alliance of DNA-Damage Response Network with Cell-cycle Checkpoints Amid Events of Uncontrolled Cellular Proliferation: A Mini- Review


Aroni Chatterjee, Keshav Rajarshi, Rajni Khan, Hiya Ghosh, Sonia Kapoor* and Shashikant Ray *   Pages 1 - 7 ( 7 )


There is close interdependence between cell survival, cell senescence, events of the cell cycle, apoptosis, malignancy development, and tumor responses to cancer treatment. Intensive studies and elaborate researches have been conducted on the functional aspects of oncogenes, tumor suppressor genes, apoptotic genes, and members guiding cell cycle regulation. These disquisitions have put forward the existence of a highly organized response pathway termed as a DNAdamage response network. The pathways detecting DNA damage and signaling are intensively linked to the events of cellcycle arrest, cell proliferation, apoptosis, and cell senescence. DNA damage responses are complex systems that incorporate specific "sensor" and "transducer" proteins, for assessment of damage and signal transmission, respectively. These signals are thereafter relayed upon various "effector" proteins involved in different cellular pathways. It may include those governing cell-cycle checkpoints, participating in DNA repair, cell senescence, and apoptosis. This review discusses about the role of tumour suppressor gene, oncogenes, cell cycle checkpoint regulators during DNA damage response and regulation.


Cancer, cell cycle, checkpoint, DNA damage, oncogene, tumor suppressor


Virus Research Laboratory, NICED, Kolkata 700010 West Bengal, 2School of Community Science and Technology (SOCSAT) Indian Institute of Engineering Scince and Technology (IIEST), Shibpur, Howrah, West Bengal711103, Motihari College of Engineering, Motihari, Bihar 845401, Bihar, Department of Endocrinology& Metabolism, IPGMER & SSKM Hospital, Kolkata, West Bengal, Amity Institute of Molecular Medicine and Stem Cell Research Amity University, Noida, Department of Biotech, Mahatma Gandhi Central University, Motihari 845401, Bihar

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