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MicroRNA Expression Levels in Patients with Hashimoto Thyroiditis: A Single Centre Study

[ Vol. 21 , Issue. 6 ]

Author(s):

Hale O. Yilmaz*, Alper H. Cebi, Mustafa Kocak, Halil O. Ersoz and Mevlit Ikbal   Pages 1066 - 1072 ( 7 )

Abstract:


Objective: To determine the circulatory miRNA expression levels in patients with Hashimoto thyroiditis (HT) at the time of diagnosis and follow-up period compared with healthy controls.

Methods: We collected blood samples from 34 patients with HT (4 males and 30 females) at the time of first diagnosis (Group P) and euthyroid period (Group E). Thirty-three healthy controls (Group H) blood samples were also included in the study. Expression levels of five different circulating miRNAs (miR-22, miR-141, miR-155, miR-375, miR-451) were evaluated using real-time polymerase chain reaction.

Results: There was a significant difference in miR-375 levels between the groups P and H. Also, for miR-451, there was a significant difference between the P and E groups. Finally, there was a moderate positive correlation between thyroid-stimulating hormone values and miR-22 expression levels for the P group.

Conclusion: miRNAs have important roles at all stages of the diseases. More studies must be performed in all thyroid diseases and autoimmune diseases, including HT.

Keywords:

Circulatory miRNA, Hashimoto thyroiditis, miR-451, miR-375, miR-22, autoimmune condition.

Affiliation:

Department of Medical Genetics, Faculty of Medicine, Karadeniz Technical University,Trabzon, Department of Medical Genetics, Faculty of Medicine, Karadeniz Technical University,Trabzon, Department of Endocrinology and Metabolism, Faculty of Medicine, Karadeniz Technical University, Trabzon, Department of Endocrinology and Metabolism, Faculty of Medicine, Karadeniz Technical University, Trabzon, Department of Medical Genetics, Faculty of Medicine, Karadeniz Technical University,Trabzon



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