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Berberine as a Potential Multi-Target Agent for Metabolic Diseases: A Review of Investigations for Berberine

[ Vol. 21 , Issue. 6 ]

Author(s):

Shengju Wang, Zhang Xu, Baochao Cai and Qiu Chen*   Pages 971 - 979 ( 9 )

Abstract:


Berberine (BBR) is a botanic alkaloid extracted from Coptis chinensis (Huanglian), which has various properties, compassing anti-hyperglycemia, anti-obesity, anti-inflammation, and improves insulin resistance, etc. Several researches have confirmed that BBR has effective actions in treating glycolipid metabolic abnormalities. BBR is also beneficial in regulating intestinal flora. Metabolic diseases are strongly associated with metabolic disorders, which are growing in the population and dramatically impacting human health, which also have been considered as a leading cause of diseases and death globally. This review is to evaluate the metabolic properties of BBR, and its potential application to the treatment of metabolic diseases by its effective actions on metabolic disorders.

Keywords:

berberine, metabolic disorders, insulin resistance, chronic inflammatory, type 2 diabetes, nonalcoholic fatty liver disease, intestinal floraberberine, metabolic disorders, insulin resistance, chronic inflammatory, type 2 diabetes, nonalcoholic fatty liver disease, intestinal flora

Affiliation:

Department of Endocrinology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, Department of Endocrinology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, Endocrinology Department, Jiaxing Hospital of Traditional Chinese Medicine, Jiaxing 314001, Department of Endocrinology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072



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