Shahzad Khan*, Syed S. Ahmad and Mohammad A. Kamal Pages 268 - 281 ( 14 )
Diabetic cardiomyopathy (DCM) is a significant complication of diabetes mellitus characterized by gradually failing heart with detrimental cardiac remodelings, such as fibrosis and diastolic and systolic dysfunction, which is not directly attributable to coronary artery disease. Insulin resistance and resulting hyperglycemia is the main trigger involved in the initiation of diabetic cardiomyopathy. There is a constellation of many pathophysiological events, such as lipotoxicity, oxidative stress, inflammation, inappropriate activation of the renin-angiotensin-aldosterone system, dysfunctional immune modulation promoting increased rate of cardiac cell injury, apoptosis, and necrosis, which ultimately culminates into interstitial fibrosis, cardiac stiffness, diastolic dysfunction, initially, and later systolic dysfunction too. These events finally lead to clinical heart failure of DCM. Herein, The pathophysiology of DCM is briefly discussed. Furthermore, potential therapeutic strategies currently used for DCM are also briefly mentioned.
Diabetic cardiomyopathy, pathophysiology, heart failure, hyperglycemia, insulin resistance, diabetes mellitus.
Department of Pathophysiology, Wuhan University School of Medicine, Hubei, Wuhan, Department of Bioengineering, Faculty of Engineering, Integral University, Lucknow, King Fahd Medical Research Center, King Abdulaziz University, P.O. Box 80216, Jeddah 21589