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Downregulation of miR-140 is Correlated with Poor Prognosis and Progression of Thyroid Cancer

[ Vol. 21 , Issue. 4 ]

Author(s):

Qianqian Yu, Wenhai Sun, Hui Hua, Yulian Chi, Xiaomin Liu, Anbing Dong, Yinghe Sun, Jianhua Zhang and Ge Guan*   Pages 749 - 755 ( 7 )

Abstract:


Background: The incidence of thyroid cancer is increasing rapidly and there is an urgent need to explore novel therapeutic targets for thyroid cancer. MiR-140 has been reported to affect the progression of various cancers, which makes it possible to play a role in thyroid cancer. This study aimed to investigate the expression and role of miR-140 in thyroid cancer.

Methods: The expression of miR-140 was investigated by reverse transcription-quantitative polymerase chain reaction (qRT-PCR) in thyroid cancer tissues and cell lines. The prognostic value of miR- 140 in thyroid cancer was evaluated by Kaplan-Meier survival and Cox regression. Moreover, the effects of miR-140 on cell proliferation, migration, and invasion of thyroid cancer were investigated by CCK-8 and Transwell assay.

Results: MiR-140 was downregulated in thyroid cancer tissues and cells, which correlated with TNM stage and lymph node metastasis of patients. Patients with low miR-140 expression had a shorter survival time compared with that in patients with high miR-140 expression. Furthermore, miR-140 acts as an independent factor for the prognosis of thyroid cancer. Overexpression of miR-140 inhibited cell proliferation, migration, and invasion of thyroid cancer.

Conclusion: MiR-140 can serve as a potential prognostic factor for patients with thyroid cancer and suppress the progression of thyroid cancer, which provides new insight for the therapeutic target for thyroid cancer.

Keywords:

microRNA-140, thyroid cancer, prognosis, progression, therapeutic target, proliferation.

Affiliation:

Department of Thyroid Surgery, The Affiliated Hospital of Qingdao University, Qingdao, 266003, Department of Thyroid Surgery, The Affiliated Hospital of Qingdao University, Qingdao, 266003, Department of Thyroid Surgery, The Affiliated Hospital of Qingdao University, Qingdao, 266003, Medical Record Management Center, The Affiliated Hospital of Qingdao University, Qingdao, 266003, Department of Thyroid Surgery, The Affiliated Hospital of Qingdao University, Qingdao, 266003, Department of Thyroid Surgery, The Affiliated Hospital of Qingdao University, Qingdao, 266003, Department of Thyroid Surgery, The Affiliated Hospital of Qingdao University, Qingdao, 266003, Department of Thyroid Surgery, The Affiliated Hospital of Qingdao University, Qingdao, 266003, Hepatic Disease Center, The Affiliated Hospital of Qingdao University, Qingdao, 266003

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