Submit Manuscript  

Article Details


Antihyperglycemic and Antihyperlipidemic Effects of Lippia citriodora in Rats

[ Vol. 21 , Issue. 4 ]

Author(s):

Fadwa El-Ouady and Mohamed Eddouks*   Pages 711 - 719 ( 9 )

Abstract:


Aim: The study was conducted to assess the antidiabetic and antihyperlipidemic effects of Lippia citriodora.

Background: Lippia citriodora Kunth (Verbenaceae) is a medicinal plant with many traditional uses.

Objective: The goal of this study was to investigate the antidiabetic activity of aqueous extract of Lippia citriodora and its capacity to improve the lipid profile in diabetic rats.

Methods: Normal and diabetic rats were treated orally for 15 days by the leaves aqueous extract of Lippia citriodora (LCLAE) (100 mg/kg). The whole glucose utilization and liver architecture were also evaluated. The in vitro antioxidant activity of LCLAE was also assessed.

Results: LCLAE lowered blood glucose and lipid levels in all groups. Moreover, LCLAE ameliorated the liver structure and exhibited antioxidant activity.

Conclusion: In conclusion, this study demonstrates the hypoglycemic and antihyperlipidemic effects of LCLAE in rats.

Keywords:

Antidiabetic, antihyperlipidemic, Lippia citriodora, histopathology, antioxidant activity, liver, streptozotocin, medicinal plant.

Affiliation:

Departments of Ethnopharmacology and Pharmacognosy, Faculty of Sciences and Techniques Errachidia, Moulay Ismail University of Meknes, BP 509, Boutalamine 52000, Errachidia, Departments of Ethnopharmacology and Pharmacognosy, Faculty of Sciences and Techniques Errachidia, Moulay Ismail University of Meknes, BP 509, Boutalamine 52000, Errachidia

Graphical Abstract:



Read Full-Text article