Submit Manuscript  

Article Details


Effects of a Low Carb Diet and Whey Proteins on Anthropometric, Hematochemical, and Cardiovascular Parameters in Subjects with Obesity

[ Vol. 20 , Issue. 10 ]

Author(s):

Giovanni De Pergola*, Roberta Zupo, Luisa Lampignano, Silvia Paradiso, Isanna Murro, Annagrazia Cecere, Nicola Bartolomeo, Marco M. Ciccone, Gianluigi Giannelli and Vincenzo Triggiani   Pages 1719 - 1725 ( 7 )

Abstract:


Background: The best way to lose body weight, without using drugs and/or suffering hunger and stress, has not yet been defined. The present study tested a low carbohydrate diet, enriched with proteins, in subjects with overweight and obesity.

Methods: The study enrolled 22 uncomplicated overweight and obese subjects. Several parameters were examined before and after 6 weeks of a low-carbohydrate diet, enriched with 18 g of whey proteins. Anthropometric (body mass index, waist circumference) variables, fasting hormones (insulin, TSH, FT3, FT4), and metabolic (glucose, prealbumin, and lipid levels) parameters were measured. 25- OH-vitamin D (25 (OH) D), parathyroid hormone (PTH) and osteocalcin, were also quantified. Body composition parameters (fat mass, fat-free mass, body cell mass, total body water) were measured by electrical bioimpedance analysis. As cardiovascular parameters, blood pressure, endothelium flowmediated dilation (FMD), and common carotid artery intima-media thickness were also measured.

Results: The low-carbohydrate diet integrated with proteins induced a significant decrease in body weight (P < 0.001), waist circumference (P < 0.001), fat mass (P < 0.001), diastolic blood pressure (P < 0.01), triglycerides (P < 0.001), total cholesterol (P < 0.001), pre-albumin (P < 0.001), insulin (P < 0.001), HOMAIR (P < 0.001), FT3 (P < 0.05), and c-IMT (P < 0.001), and a significant increase in FMD (P < 0.001) and 25 (OH) D (P < 0.001) was also observed.

Conclusion: All these results suggest that a short-term non-prescriptive low carbohydrate diet, enriched with whey proteins, may be a good way to start losing fat mass and increase health.

Keywords:

Low carbohydrate diet, whey proteins, endothelium, intima-media thickness, obesity, overweight.

Affiliation:

Clinical Nutrition Unit, Medical Oncology, Department of Biomedical Science and Human Oncology, University of Bari, School of Medicine, Policlinico, Piazza Giulio Cesare 11, 70124 Bari, National Institute of Gastroenterology “S. de Bellis”, Research Hospital, Castellana Grotte, National Institute of Gastroenterology “S. de Bellis”, Research Hospital, Castellana Grotte, Clinical Nutrition Unit, Medical Oncology, Department of Biomedical Science and Human Oncology, University of Bari, School of Medicine, Policlinico, Piazza Giulio Cesare 11, 70124 Bari, Clinical Nutrition Unit, Medical Oncology, Department of Biomedical Science and Human Oncology, University of Bari, School of Medicine, Policlinico, Piazza Giulio Cesare 11, 70124 Bari, Section of Cardiovascular Disease, Department of Organ Transplantation, University of Bari, School of Medicine, Policlinico, Piazza Giulio Cesare 11, 70124, Bari, Medical Statistics, Department of Biomedical Science and Human Oncology, University of Bari, School of Medicine, Policlinico, Piazza Giulio Cesare 11, 70124 Bari, Section of Cardiovascular Disease, Department of Organ Transplantation, University of Bari, School of Medicine, Policlinico, Piazza Giulio Cesare 11, 70124, Bari, Scientific Direction, National Institute of Gastroenterology "Saverio de Bellis", Research Hospital, Castellana Grotte, 70013 Bari, Section of Endocrinology and Metabolic Diseases, Department of Emergency and Organ Transplantation University of Bari, School of Medicine, Policlinico, Piazza Giulio Cesare 11, 70124 Bari



Read Full-Text article