Submit Manuscript  

Article Details


Molecular and Immunological Mechanisms Underlying the Various Pharmacological Properties of the Potent Bioflavonoid, Rutin

[ Vol. 20 , Issue. 10 ]

Author(s):

David O.C. Yong, Sanggetha R. Saker, Dinesh K. Chellappan*, Thiagarajan Madheswaran, Jithendra Panneerselvam, Hira Choudhury, Manisha Pandey, Yik L. Chan, Trudi Collet, Gaurav Gupta, Brian G. Oliver, Peter Wark, Nicole Hansbro, Alan Hsu, Philip M. Hansbro, Kamal Dua* and Farrukh Zeeshan   Pages 1590 - 1596 ( 7 )

Abstract:


The application of medicinal plants has captured the interest of researchers in recent times due to their potent therapeutic properties and a better safety profile. The prominent role of herbal products in treating and preventing multiple diseases dates back to ancient history and most of the modern drugs today originated from their significant sources owing to their ability to control multiple targets via different signalling pathways. Among them, flavonoids consist of a large group of polyphenols, which are well known for their various therapeutic benefits. Rutin is considered one of the attractive phytochemicals and important flavonoids in the pharmaceutical industry due to its diverse pharmacological activities via various underlying molecular mechanisms. It is usually prescribed for various disease conditions such as varicosities, haemorrhoids and internal haemorrhage. In this review, we have discussed and highlighted the different molecular mechanisms attributed to the various pharmacological activities of rutin, such as antioxidant, anti-inflammatory, anticancer, anti-allergic and antidiabetic. This review will be beneficial to herbal, biological and molecular scientists in understanding the pharmacological relevance of rutin at the molecular level.

Keywords:

Rutin, molecular mechanisms, antioxidant, anti-inflammatory, anticancer, anti-allergic, anti-diabetic.

Affiliation:

School of Pharmacy, International Medical University (IMU), Bukit Jalil, Kuala Lumpur, 57000, School of Pharmacy, International Medical University (IMU), Bukit Jalil, Kuala Lumpur, 57000, Department of Life Sciences, School of Pharmacy, International Medical University (IMU), Bukit Jalil, Kuala Lumpur, 57000, Department of Pharmaceutical Technology, School of Pharmacy, International Medical University (IMU), Bukit Jalil, Kuala Lumpur, 57000, Department of Pharmaceutical Technology, School of Pharmacy, International Medical University (IMU), Bukit Jalil, Kuala Lumpur, 57000, Department of Pharmaceutical Technology, School of Pharmacy, International Medical University (IMU), Bukit Jalil, Kuala Lumpur, 57000, Department of Pharmaceutical Technology, School of Pharmacy, International Medical University (IMU), Bukit Jalil, Kuala Lumpur, 57000, School of Life Sciences, Faculty of Science, University of Technology Sydney (UTS), Ultimo, NSW 2007, Innovative Medicines Group, Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Brisbane, Queensland 4059, School of Pharmaceutical Sciences, Jaipur National University, Jagatpura, 302017, Jaipur, School of Life Sciences, Faculty of Science, University of Technology Sydney (UTS), Ultimo, NSW 2007, Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute (HMRI) & School of Biomedical Sciences and Pharmacy, The University of Newcastle, Callaghan, NSW 2308, School of Life Sciences, Faculty of Science, University of Technology Sydney (UTS), Ultimo, NSW 2007, Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute (HMRI) & School of Biomedical Sciences and Pharmacy, The University of Newcastle, Callaghan, NSW 2308, School of Life Sciences, Faculty of Science, University of Technology Sydney (UTS), Ultimo, NSW 2007, Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute (HMRI) & School of Biomedical Sciences and Pharmacy, The University of Newcastle, Callaghan, NSW 2308, Department of Pharmaceutical Technology, School of Pharmacy, International Medical University (IMU), Bukit Jalil, Kuala Lumpur, 57000



Read Full-Text article