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MicroRNAs as Biomarker for Breast Cancer

[ Vol. 20 , Issue. 10 ]

Author(s):

Taru Aggarwal, Ridhima Wadhwa, Riya Gupta, Keshav Raj Paudel, Trudi Collet, Dinesh Kumar Chellappan, Gaurav Gupta, Haribalan Perumalsamy, Meenu Mehta, Saurabh Satija*, Philip M. Hansbro, Kamal Dua and Pawan Kumar Maurya*   Pages 1597 - 1610 ( 14 )

Abstract:


Regardless of advances in detection and treatment, breast cancer affects about 1.5 million women all over the world. Since the last decade, genome-wide association studies (GWAS) have been extensively conducted for breast cancer to define the role of miRNA as a tool for diagnosis, prognosis and therapeutics. MicroRNAs are small, non-coding RNAs that are associated with the regulation of key cellular processes such as cell multiplication, differentiation, and death. They cause a disturbance in the cell physiology by interfering directly with the translation and stability of a targeted gene transcript. MicroRNAs (miRNAs) constitute a large family of non-coding RNAs, which regulate target gene expression and protein levels that affect several human diseases and are suggested as the novel markers or therapeutic targets, including breast cancer. MicroRNA (miRNA) alterations are not only associated with metastasis, tumor genesis but also used as biomarkers for breast cancer diagnosis or prognosis. These are explained in detail in the following review. This review will also provide an impetus to study the role of microRNAs in breast cancer.

Keywords:

micro-RNA, breast cancer, oncomirs, oncosuppressormir, drug targeting, drug resistance.

Affiliation:

Amity Institute of Biotechnology, Amity University, Noida, 201303, Uttar Pradesh, Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Ultimo, NSW, 2007, Amity Institute of Biotechnology, Amity University, Noida, 201303, Uttar Pradesh, Centre for Inflammation, Centenary Institute, Sydney, NSW, 2050, Australia Callaghan, NSW, 2308, Indigenous Medicines Group, Institute of Health & Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Brisbane, Queensland, 4059, Department of Life Sciences, School of Pharmacy, International Medical University, Bukit Jalil, Kuala Lumpur 57000, School of Pharmaceutical Sciences, Jaipur National University, Jagatpura, 302017, Jaipur, Graduate School of Biotechnology, College of Life Science, Kyung Hee University, Yongin, 446-701, School of Pharmaceutical Sciences, Lovely Professional University, Jalandhar-Delhi G.T. Road (NH-1), Phagwara-144411, Punjab, School of Pharmaceutical Sciences, Lovely Professional University, Jalandhar-Delhi G.T. Road (NH-1), Phagwara-144411, Punjab, Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute (HMRI) & School of Biomedical Sciences and Pharmacy, University of Newcastle, Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute (HMRI) & School of Biomedical Sciences and Pharmacy, University of Newcastle, Department of Biochemistry, Central University of Haryana, Jant-Pali, Mahendergarh District, 123031, Haryana



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