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Association of Interleukin-1 and Inteleukin-1 Receptor Antagonist Gene Polymorphisms with Multiple Sclerosis in Azeri Population of Iran

Author(s):

Mohammad Asgharzadeh, Zahra Ashrafi Jigheh, Hossein Samadi Kafil, Mehdi Farhoudi, Daryoush Savadi Oskouei, Fatemeh Khaki-Khatibi, Manouchehr Fadaee , Ali Vegari, Vahid Asgharzadeh, Nima Najafi-Ghalelou, Behroz Mahdavi Poor and Jalil Rashedi*   Pages 1 - 7 ( 7 )

Abstract:


Aims:The aim of the present study was to evaluate the possible correlation between MS and IL-1 related alleles in Azeri population of Iran

Background:Cytokines as important mediators have a critical role in appropriate immune responses which irregular production of the mediators can lead to Multiple Sclerosis (MS). Proinflammatory cytokine interleukin-1 (IL-1), trigger inflammatory responses. Function and production of the cytokine are influenced by IL-1 coding gene polymorphism and those antagonists gene polymorphism.

Objective:The aim of the present study was to evaluate the possible correlation between MS and IL-1 related alleles in Azeri population of Iran

Method:Variable number tandem repeats (VNTR) genotypes of 150 MS patients and 220 healthy non-relative controls were determined.

Result:In the healthy controls, genotype TT at IL-1A (-889) location was significantly higher than the MS patients (p=0.0001). However, a significant difference was not found between the two groups in genotypic/allelic frequency at IL- 1B+ 3953 location. Evaluation of the IL-1RA gene revealed that genotype 1/2, and genotype 1/3 were significantly higher in the healthy controls and MS patients, respectively. Our findings indicated that the consumption of fast-food in MS patients was significantly higher than controls (p= <0.05). Also, a considerable number of MS patients had inappropriate dieting behaviors such as not eating breakfast (p= 0.0001), and irregular eating habits (p= 0.0001).

Keywords:

IL-1A, IL-1B, IL-1RA, polymorphism, multiple sclerosis, Iran

Affiliation:

Tabriz University of Medical Sciences, Laboratory Science, Hematology and Oncology Research Center, Department of laboratory Sciences, Faculty of Paramedicine, Tabriz University of Medical Sciences, Tabriz, Tabriz University of Medical Sciences, Drug Applied Research Center, Department of laboratory Sciences, Faculty of Paramedicine, Tabriz University of Medical Sciences, Tabriz, Department of laboratory Sciences, Faculty of Paramedicine, Tabriz University of Medical Sciences, Tabriz, Tabriz University of Medical Sciences, Drug Applied Research Center and Department of Clinical Biochemistry, Tabriz University of Medical Sciences, Laboratory Science, Department of laboratory Sciences, Faculty of Paramedicine, Tabriz University of Medical Sciences, Tabriz, Department of laboratory Sciences, Faculty of Paramedicine, Tabriz University of Medical Sciences, Tabriz, Department of laboratory Sciences, Faculty of Paramedicine, Tabriz University of Medical Sciences, Tabriz, Tabriz University of Medical Sciences, Laboratory Science, Tabriz University of Medical Sciences, Immunology Research Center



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