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Association of Interleukin-1 and Inteleukin-1 Receptor Antagonist Gene Polymorphisms with Multiple Sclerosis in Azeri Population of Iran

[ Vol. 20 , Issue. 7 ]

Author(s):

Mohammad Asgharzadeh, Zahra A. Jigheh, Hossein S. Kafil, Mehdi Farhoudi, Daryoush S. Oskouei, Fatemeh Khaki-Khatibi, Manouchehr Fadaee , Ali Vegari, Vahid Asgharzadeh, Nima Najafi-Ghalelou, Behroz M. Poor and Jalil Rashedi*   Pages 1110 - 1116 ( 7 )

Abstract:


Background: Cytokines as important mediators have a critical role in appropriate immune responses, the irregular production of which can lead to Multiple Sclerosis (MS). Proinflammatory cytokine interleukin-1 (IL-1) triggers inflammatory responses. Function and production of the cytokine are influenced by IL-1 coding gene polymorphism and those antagonists gene polymorphism.

Objective: The aim of the present study was to evaluate the possible correlation between MS and IL-1 related alleles in Azeri population of Iran.

Methods: Variable number tandem repeats (VNTR) genotypes of 150 MS patients and 220 healthy non-relative controls were determined.

Results: In the healthy controls, genotype TT at IL-1A (-889) location was significantly higher than the MS patients (p=0.0001). However, a significant difference was not found between the two groups in genotypic/allelic frequency at IL- 1B+ 3953 location. Evaluation of the IL-1RA gene revealed that genotype 1/2, and genotype 1/3 were significantly higher in the healthy controls and MS patients, respectively. Our findings indicated that the consumption of fast-food in MS patients was significantly higher than controls (p= <0.05). Also, a considerable number of MS patients had inappropriate dieting behaviors such as not eating breakfast (p= 0.0001), and irregular eating habits (p= 0.0001).

Conclusion: Polymorphisms of the IL-1B genes and common alleles of IL-1RA were not considered as risk factors for MS disease. However, genotype TT at IL-1A (-889) location and the rare allele of IL-1RA3 can be a potential risk factor for the disease. Furthermore, inappropriate dieting behaviors and consumption of fast-food can increase the risk of MS.

Keywords:

IL-1A, IL-1B, IL-1RA, polymorphism, multiple sclerosis, Iran.

Affiliation:

Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Department of Clinical Biochemistry, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Neurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, Neurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, Department of Clinical Biochemistry, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Department of Immunology, Shiraz University of Medical Sciences, Shiraz, Department of Medical Physics, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Department of Laboratory Sciences, Faculty of Paramedicine, Tabriz University of Medical Sciences, Tabriz, Department of Laboratory Sciences, Faculty of Paramedicine, Tabriz University of Medical Sciences, Tabriz, Department of Laboratory Sciences, Faculty of Paramedicine, Tabriz University of Medical Sciences, Tabriz



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