Submit Manuscript  

Article Details


Exploring the Protective Effect of ShenQi Compound on Skeletal Muscle in Diabetic Macrovasculopathy Mice

Author(s):

Yuhong Duan , Hong Gao, Hongxia Su, Aixia Liu, Ya Liu, Haipo Yuan and Chunguang Xie*   Pages 1 - 9 ( 9 )

Abstract:


Objective: ShenQi compound (SQC) is a traditional herbal formula, which has been used to treat Type 2 diabetes mellitus (T2DM) and complications for years. The aim of this study is to explore the preventive and protective effects of SQC recipe on the skeletal muscle of diabetic macrovasculopathy, and provide a theoretical basis for the clinical use of this formula.

Methods: We evaluated the effect of SQC in a diabetic vasculopathy mouse model by detecting a series of blood indicators (blood glucose, lipids and insulin) and performing histological observations. Meanwhile, we explored the molecular mechanism of SQC treatment on skeletal muscle by genome expression profiles.

Results: The results indicated that SQC could effectively improve blood glucose, serum lipids (total cholesterol (TC), Triglyceride (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C)) and insulin (INS) levels on diabetic vasculopathy mice, as well as alleviating skeletal muscle tissue damage for diabetic macrovasculopathy. Meanwhile, compared with rosiglitazone, SQC achieved a better effect on blood glucose fluctuation. Moreover, the gene microarray analysis indicated that SQC might improve T2DM by affecting biological functions related to cell death and cell adhesion. Moreover 7 genes (Celsr2, Rilpl1, Dlx6as, 2010004M13Rik, Anapc13, Gm6097, Ddx39b) might be potential therapeutic targets of SQC.

Conclusion: All these results indicate that SQC is an effective preventive and protective drug on skeletal muscle of diabetic macrovasculopathy, and could alleviate skeletal muscle tissue damage through affecting biological functions related to cell death and cell adhesion.

Keywords:

Type 2 Diabetes Mellitus, diabetic macrovasculopathy, skeletal muscle, traditional Chinese medicine, gene microarray, ShenQi compound

Affiliation:

Department Two of Endocrinology, Teaching Hospital, Shaanxi University of Traditional Chinese Medicine, Xianyang, Department of Endocrinology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, 610072, Department Two of Endocrinology, Teaching Hospital, Shaanxi University of Traditional Chinese Medicine, Xianyang, Department Two of Endocrinology, Teaching Hospital, Shaanxi University of Traditional Chinese Medicine, Xianyang, Department of Endocrinology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, 610072, Department of Endocrinology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, 610072, Department of Endocrinology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, 610072



Read Full-Text article