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Pathogenic Mechanisms and Therapeutic Implication in Nickel-induced Cell Damage

Author(s):

Ahmad Salimi*, Zhaleh Jamali, Saman Atashbar, Saleh Khezri, Amir Mohammad Ghorbanpour and Nahid Etefaghi   Pages 1 - 17 ( 17 )

Abstract:


Background: Nickel (Ni) is mostly applied in plenty industrial sections like printing inks, welding, alloy, electronics and electrical professions. Occupational or environmental exposure to nickel may lead to cancer, allergy reaction, nephrotoxicity, hepatotoxicity, neurotoxicity as well as cell damage, apoptosis and oxidative stress.

Method: In here we focused on published studies about cell death, carcinogenicity, allergy reactions and neurotoxicity, and promising agents for prevention and treatment the toxicity by Ni.

Results: Our review showed that in last years, more researches have focused on reactive oxygen species formation, oxidative stress, DNA damages, apoptosis, interaction with involving receptors in allergy and mitochondrial damages in neuron induced by Ni.

Conclusion: The gathering data in this paper provides useful information about the main toxicities induced by Ni also, their fundamental mechanisms, and how to discover new ameliorative agents for prevention and treatment, by reviewing agents with protective and therapeutic consequences on Ni induced toxicity.

Keywords:

Nickel, Cell Death, Carcinogenicity, Allergy Reactions, Neurotoxicity, Mechanisms

Affiliation:

Department of Pharmacology and Toxicology, School of Pharmacy, Ardabil University of Medical Sciences, Ardabil, Student Research Committee, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Department of Pharmacology and Toxicology, School of Pharmacy, Ardabil University of Medical Sciences, Ardabil, Department of Pharmacology and Toxicology, School of Pharmacy, Ardabil University of Medical Sciences, Ardabil, Department of Pharmacology and Toxicology, School of Pharmacy, Ardabil University of Medical Sciences, Ardabil, Department of Pharmacology and Toxicology, School of Pharmacy, Ardabil University of Medical Sciences, Ardabil



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