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Italian Association of Clinical Endocrinologists (AME) and Italian AACE Chapter Position Statement for Clinical Practice: Acromegaly - Part 1: Diagnostic and Clinical Issues

[ Vol. 20 , Issue. 8 ]

Author(s):

Renato Cozzi*, Maria R. Ambrosio, Roberto Attanasio, Alessandro Bozzao, Laura De Marinis, Ernesto De Menis, Edoardo Guastamacchia, Andrea Lania, Giovanni Lasio, Francesco Logoluso, Pietro Maffei, Maurizio Poggi, Vincenzo Toscano, Michele Zini, Philippe Chanson and Laurence Katznelson   Pages 1133 - 1143 ( 11 )

Abstract:


Acromegaly is a rare disease. Improvements in lifespan in these patients have recently been reported due to transsphenoidal surgery (TSS), advances in medical therapy, and strict criteria for defining disease remission. This document reports the opinions of a group of Italian experts who have gathered together their prolonged clinical experience in the diagnostic and therapeutic challenges of acromegaly patients. Both GH and IGF-I (only IGF-I in those treated with Pegvisomant) are needed in the diagnosis and follow-up. Comorbidities (cardio-cerebrovascular disease, sleep apnea, metabolic derangement, neoplasms, and bone/joint disease) should be specifically addressed. Any newly diagnosed patient should be referred to a multidisciplinary team experienced in the treatment of pituitary adenomas.

Keywords:

Acromegaly, pituitary, comorbidities, discrepant, GH, IGF-I.

Affiliation:

Division of Endocrinology, Niguarda Hospital, Milan, 2Section of Endocrinology and Internal Medicine, Department of Medical Sciences, University of Ferrara, Ferrara, Endocrinology Service, IRCCS Orthopedic Institute Galeazzi, Milan, Neuroradiology, S. Andrea Hospital, NESMOS Department (Neuroscience, Mental Health, Sensorial Organs), Sapienza University of Rome, Rome, Pituitary Unit, Department of Endocrinology, Catholic University of the Sacred Heart, School of Medicine, Rome, Department of Internal Medicine, General Hospital, Montebelluna (TV), AME President, University of Bari, Bari, Department of Biomedical Sciences, Humanitas University and Endocrinology Unit, Humanitas Research Hospital, Rozzano, Department of Neurosurgery, Humanitas University and Endocrinology Unit, Humanitas Research Hospital, Rozzano, Endocrinology Unit, Department of Emergency and Organ Transplantation, University Medical School 'Aldo Moro', Bari, 11Department of Medicine (DIMED), 3rd Medical Clinic, Padua University Hospital, Padua, Endocrinology, Department of Clinical and Molecular Medicine, S. Andrea Hospital, Sapienza University of Rome, Rome, Endocrinology, Department of Clinical and Molecular Medicine, S. Andrea Hospital, Sapienza University of Rome, Rome, Endocrinology Unit, Azienda Ospedaliera S. Maria Nuova IRCCS, Reggio Emilia, Italy; (All on behalf of AME and AACE Italian Chapter ), Endocrinology and Reproductive Diseases, BicĂȘtre Hospital and Paris-Saclay University 11, Department of Medicine, Stanford University Hospital, Stanford, CA



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