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Cardiovascular Effects of Micromeria graeca (L.) Benth. ex Rchb in Normotensive and Hypertensive Rats

Author(s):

Mourad Akdad and Mohamed Eddouks*   Pages 1 - 9 ( 9 )

Abstract:


Aims: The present study was performed in order to analyze the antihypertensive activity of Micromeria graeca (L.) Benth. exRchb.

Background: Micromeria graeca (L.) Benth. exRchb is an aromatic and medicinal plant belonging to Lamiaceae family. This herb is used to treat various pathologies such as cardiovascular disorders. Meanwhile, its pharmacological effects on the cardiovascular system have not been studied.

Objective: The present study aimed to evaluate the effect of aqueous extract of Aerial parts of Micromeria graeca (AEMG) on the cardiovascular system in normotensive and hypertensive rats.

Methods: In this study the cardiovascular effect of AEMG was evaluated using in vivo and in vitro investigations. In order to assess the acute effect of AEMG on cardiovascular system anesthetized L-NAME-hypertensive and normotensive rats have received orally AEMG (100 mg/kg) and arterial blood pressure parameters were monitored during six hours. In the sub-chronic study, rats were orally treated over one week and blood pressure was followed during one week of treatment. Blood pressure was measured using a tail-cuff and a computer-assisted monitoring device. In the second experiment, isolated rat aortic ring pre-contracted with Epinephrine (EP) or KCl was used to assess the vasorelaxant effect of AEMG.

Results: Oral administration of AEMG (100 mg/kg) provoked a decrease of arterial blood pressure parameters in hypertensive rats. In addition, AEMG induced a vasorelaxant effect in thoracic aortic rings pre-contracted by EP (10 µM) or KCl (80 mM). This effect was attenuated in the presence of propranolol and Methylene blue. While in the presence of Glibenclamide, L-NAME, nifedipine or Indomethacin, the vasorelaxant effect was not affected.

Conclusion: This study showed that Micromeria graeca possesses a potent antihypertensive effect and relaxes the vascular smooth muscle through β-adrenergic and cGMP pathways.

Keywords:

Antihypertensive, Vasorelaxation, Micromeria graeca, β-adrenergic. L-NAME, Medicinal plant

Affiliation:

Department of Biology, Faculty of Sciences and Techniques Errachidia, Team of Endocrine Physiology and Pharmacology, Moulay Ismail University of Meknes, BP 509, Boutalamine, 52000. Errachidia, Department of Biology, Faculty of Sciences and Techniques Errachidia, Team of Endocrine Physiology and Pharmacology, Moulay Ismail University of Meknes, BP 509, Boutalamine, 52000. Errachidia



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