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Interleukin 1-beta is Linked to Chronic Low-grade Inflammation and Cardiovascular Risk Factors in Overweight Adolescents

Author(s):

Gisele A. Amaral, Josilene D. Alves, Adenilda C. Honorio-França, Danny L. Fagundes, Gabriel Gomes Araujo, Nubia S. Lobato, Victor V. Lima and Fernanda R. Giachini*   Pages 1 - 8 ( 8 )

Abstract:


Aim: We hypothesized that IL-1β concentrations are augmented in overweight adolescents, who do not display metabolic syndrome. Additionally, we aimed to correlate the IL-1β concentrations with several established risk factors for CVD.

Methods: Overweight or control subjects, aging from 14-18 years, were classified according their adjusted body mass index and evaluated for biochemical and anthropometric parameters. The pro-inflammatory cytokine IL-1β was assessed in serum.

Results: Increased body fat percentage, waist circumference, triglycerides, total cholesterol, Very Low-Density Lipoprotein (VLDL) cholesterol, Low-Density Lipoprotein (LDL) cholesterol, Castelli I index, IL-1β, and IL-8 levels, whereas were observed in overweight adolescents. No differences were observed in systolic blood pressure, diastolic blood pressure, glucose or High-Density Lipoprotein (HDL) cholesterol. Positive correlations between IL-1β with anthropometric and or biochemical parameters were found.

Conclusion: In conclusion, increased IL-1β levels correlate to dyslipidemic factors and may further support low-grade inflammation. IL-1β may further predict the early onset of cardiovascular disease within this population, taking into consideration its important regulatory role.

Keywords:

Childhood, obesity, cytokine, inflammation, cardiovascular disease, dyslipemic factors

Affiliation:

Institute of Biological Sciences and Health, Federal University of Mato Grosso – Barra do Garças – MT, Institute of Biological Sciences and Health, Federal University of Mato Grosso – Barra do Garças – MT, Institute of Biological Sciences and Health, Federal University of Mato Grosso – Barra do Garças – MT, Institute of Biological Sciences and Health, Federal University of Mato Grosso – Barra do Garças – MT, Institute of Biological Sciences and Health, Federal University of Mato Grosso – Barra do Garças – MT, Department of Biological Sciences, Division of Cardiovascular Physiology, Federal University of Goias, Jatai, Institute of Biological Sciences and Health, Federal University of Mato Grosso – Barra do Garças – MT, Institute of Biological Sciences and Health, Federal University of Mato Grosso – Barra do Garças – MT



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