Submit Manuscript  

Article Details


Interleukin 1-beta is Linked to Chronic Low-Grade Inflammation and Cardiovascular Risk Factors in Overweight Adolescents

[ Vol. 20 , Issue. 6 ]

Author(s):

Gisele A. Amaral, Josilene D. Alves, Adenilda C. Honorio-França, Danny L. Fagundes, Gabriel Gomes Araujo, Nubia S. Lobato, Victor V. Lima and Fernanda R. Giachini*   Pages 887 - 894 ( 8 )

Abstract:


Aim: We hypothesized that IL-1β concentrations are augmented in overweight adolescents, who do not display metabolic syndrome. Additionally, we aimed to correlate the IL-1β concentrations with several established risk factors for CVD.

Methods: Overweight or control subjects, aging from 14-18 years, were classified according to their adjusted body mass index and evaluated for biochemical and anthropometric parameters. The proinflammatory cytokine IL-1β was assessed in the serum.

Results: Increased body fat percentage, waist circumference, triglycerides, total cholesterol, Very Low-Density Lipoprotein (VLDL) cholesterol, Low-Density Lipoprotein (LDL) cholesterol, Castelli I index, IL-1β, and IL-8 levels, were observed in overweight adolescents. No differences were observed in systolic blood pressure, diastolic blood pressure, glucose or High-Density Lipoprotein (HDL) cholesterol. Positive correlations between IL-1β with anthropometric and or biochemical parameters were found.

Conclusion: In conclusion, increased IL-1β levels correlate to dyslipidemic factors and may further support low-grade inflammation. IL-1β may further predict the early onset of cardiovascular disease in this population, taking into consideration its important regulatory role.

Keywords:

Childhood, obesity, cytokine, inflammation, dyslipidemia, interleukins.

Affiliation:

Institute of Biological and Health Sciences, Federal University of Mato Grosso, Barra do Garcas, MT, Institute of Biological and Health Sciences, Federal University of Mato Grosso, Barra do Garcas, MT, Institute of Biological and Health Sciences, Federal University of Mato Grosso, Barra do Garcas, MT, Institute of Biological and Health Sciences, Federal University of Mato Grosso, Barra do Garcas, MT, Institute of Biological and Health Sciences, Federal University of Mato Grosso, Barra do Garcas, MT, Department of Biological Sciences, Division of Cardiovascular Physiology, Federal University of Goias, Jatai, Institute of Biological and Health Sciences, Federal University of Mato Grosso, Barra do Garcas, MT, Institute of Biological and Health Sciences, Federal University of Mato Grosso, Barra do Garcas, MT

Graphical Abstract:



Read Full-Text article