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Evaluation of Salivary Antioxidants and Oxidative Stress Markers in Type 2 Diabetes Mellitus: A Retrospective Cohort Study

[ Vol. 20 , Issue. 4 ]


Shima Fathi, Shiva Borzouei, Mohammad Taghi Goodarzi, Jalal Poorolajal and Fatemeh Ahmadi-Motamayel*   Pages 584 - 590 ( 7 )


Background: Diabetes Mellitus (DM) is a progressive metabolic disorder.

Objective: The aim of this study was to investigate the relationship between antioxidant and oxidative stress markers in the saliva of patients with type 2 DM and a healthy control group.

Methods: In this study, 20 patients with diabetes and 20 healthy individuals were evaluated. Salivary antioxidants markers consisted of total antioxidant capacity (TAC), uric acid (UA), peroxidase and catalase. Oxidative stress markers included total oxidant status (TOS), malondealdehyde (MDA) and total thiol (SH). Sialochemical analysis was performed with spectrophotometric assay. All the statistical analyses were conducted using STATA software.

Results: TAC decreased significantly in patients with diabetes. Although salivary UA and peroxidase were lower in patients with diabetes compared to the control group, the difference was not significant. Salivary catalase in patients with diabetes was significantly lower than that in the control group. MDA and TOS exhibited significantly higher levels in type 2 DM. SH levels were slightly higher in DM.

Conclusion: According to the results of the present study, there were some changes in the salivary levels of some antioxidants and oxidative stress markers in patients with type 2 DM and could be measured as an indicator of serum changes.


Diabetes mellitus, malondealdehyde, oxidative stress, saliva, total antioxidant capacity.


Department of Oral Medicine, Dental School, Lorestan University of Medical Sciences, Khorramabad, Diabetes Research Center, Department of Endocrinology, Hamadan University of Medical Sciences, Hamadan, Department of Biochemistry, Shahrood Branch, Islamic Azad University, Shahrood, Research Center for Health Sciences and Department of Epidemiology, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Dental Research Center and Dental Implant Research Center, Department of Oral Medicine, Hamadan University of Medical Sciences, Hamadan

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