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The Herbicide Glyphosate and Its Apparently Controversial Effect on Human Health: An Updated Clinical Perspective

[ Vol. 20 , Issue. 4 ]

Author(s):

Carlo Caiati*, Paolo Pollice, Stefano Favale and Mario Erminio Lepera   Pages 489 - 505 ( 17 )

Abstract:


Background: Glyphosate (G) is the most common weed-killer in the world. Every year tons and tons of G are applied on crop fields. G was first introduced in the mid 1970s and since then its usage has gradually increased to reach a peak since 2005. Now G usage is approximately 100 -fold what it was in 1970. Its impact on human health was considered benign at the beginning. But over the years, evidence of a pervasive negative effect of this pesticide on humans has been mounting. Nonetheless, G usage is allowed by government health control agencies (both in the United States and Europe), that rely upon the evidence produced by the G producer. However, the IARC (International Agency for Research on Cancer) in 2015 has stated that G is probable carcinogenic (class 2A), the second highest class in terms of risk.

Objective: In this review, we explore the effect of G on human health, focusing in particular on more recent knowledge.

Results: We have attempted to untangle the controversy about the dangers of the product for human beings in view of a very recent development, when the so -called Monsanto Papers, consisting of Emails and memos from Monsanto came to light, revealing a coordinated strategy to manipulate the debate about the safety of glyphosate to the company’s advantage.

Conclusion: The story of G is a recurrent one (see the tobacco story), that seriously jeopardizes the credibility of the scientific study in the modern era.

Keywords:

Glyphosate, herbicide, genotoxic damage, oxidative stress, chemical toxicity, endocrine disruptor.

Affiliation:

Department of Emergency and Organ Transplantation, Unit of Cardiovascular Diseases, University of Bari, Bari, Department of Emergency and Organ Transplantation, Unit of Cardiovascular Diseases, University of Bari, Bari, Department of Emergency and Organ Transplantation, Unit of Cardiovascular Diseases, University of Bari, Bari, Department of Emergency and Organ Transplantation, Unit of Cardiovascular Diseases, University of Bari, Bari

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