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The Expression of Hormone Receptors as a Gateway Toward Understanding Endocrine Actions in Female Pelvic Floor Muscles

Author(s):

Francisco Castelán*, Estela Cuevas-Romero and Margarita Martínez-Gómez   Pages 1 - 14 ( 14 )

Abstract:


Objective: To provide an overview about hormone actions and receptors expressed in female pelvic floor muscles relevant for understanding pelvic floor disorders.

Methods: We performed a literature review focused on the expression of hormone receptors in the pelvic floor muscles of women and female rats and rabbits, mainly.

Results: The impairment of pelvic floor muscles can lead to the onset of pelvic floor dysfunctions, including stress urinary incontinence in women. Hormone milieu is associated with structure and function alterations of pelvic floor muscles, a notion supported by the fact that these muscles express different hormone receptors. Nuclear receptors, such as steroid receptors, are insofar as the most approached. The present review accounts for the limited studies done to elucidate the expression of hormone receptors in pelvic floor muscles in females.

Conclusion: Hormone receptor expression is a cornerstone in proposing some hormone-based therapies, which require further studies to detail the distribution of receptors in particular pelvic floor muscles, as well as its associations with muscle effectors, involved in alterations relevant for understanding pelvic floor disorders.

Keywords:

androgen receptor, estrogen receptor, levator ani, micturition, reproduction, thyroid hormone receptor

Affiliation:

Department of Cellular Biology and Physiology Biomedical Research Institute, National Autonomous University of Mexico, Mexico City, Tlaxcala Center for Behavioral Biology, Autonomous University of Tlaxcala, Tlaxcala, Department of Cellular Biology and Physiology Biomedical Research Institute, National Autonomous University of Mexico, Mexico City



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