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The Association of Metabolic Syndrome and Psoriasis: A Systematic Review and Meta-Analysis of Observational Study

Author(s):

Saumya Choudhary, Dibyabhabha Pradhan, Anamika Pandey, Mohd. Kamran Khan, Rohit Lall, V Ramesh, Poonam Puri, Arun Kumar Jain and George Thomas*   Pages 1 - 15 ( 15 )

Abstract:


Background: Metabolic syndrome worsens complications in psoriasis patients by predisposing them to cardiovascular diseases. Psoriasis has been widely associated with metabolic syndrome; however, it has still not been proven owing to a limited number of studies and some of those reporting conflicting results.

Objective: Psoriasis has been reported to be associated with metabolic syndrome; however, it has still not been established beyond doubt owing to conflicting studies. Present meta-analysis of observational studies aims to assess the prevalence of metabolic syndrome in psoriasis patients.

Research Design and Methods: A systematic web search for ‘Psoriasis’, ‘Metabolic Syndrome’, ‘Hypertension’, ‘Plasma Glucose’, ‘Dyslipidaemia’, ‘Waist Circumference’ was performed, collecting all original observational studies on humans up to April 30, 2018. Depending on the inclusion and exclusion criteria, articles were screened for eligibility. Due to the presence of significant heterogeneity, the Odds Ratio (OR) was calculated using random-effect model with Der-Simonian and Laird method. The statistical heterogeneity was determined using I2 statistics. Comprehensive Meta-Analysis Software, Version 3 was used to perform all the analysis.

Results: Sixty-three studies encompassing 15939 psoriasis patients and 103984 controls were included in this meta-analysis. Among them, 30.29 % of psoriasis patients were reported with metabolic syndrome in comparison to 21.70 % subjects in the control group. The present study clearly indicates an increased prevalence of metabolic syndrome among psoriasis patients (OR: 2.077 [95% CI, 1.84 - 2.34]).

Conclusions: The findings support the fact that psoriasis patients have a higher incidence of metabolic syndrome. Our study also recommends that psoriasis patients should be regularly monitored for metabolic syndrome complications and its associated risk factors such as hypertension, raised triglyceride, lowered HDL Cholesterol, increased fasting plasma glucose, and waist circumference.

Keywords:

Psoriasis, Metabolic Syndrome, Meta-analysis, PRISMA, Odds Ratio (OR), Comprehensive Meta-Analysis Software

Affiliation:

Department of Molecular and Cellular Engineering, Sam Higginbottom University of Agriculture, Technology and Sciences, Allahabad, India -211007, Computational Genomics Centre, Informatics, Systems and Research Management (ISRM) Division- Indian Council of Medical Research, New Delhi, India-110029, Department of Soil Science and Plant Nutrition, Selcuk University, Turkey-401602. , Department of Soil Science and Plant Nutrition, Selcuk University, Turkey-401602. , Department of Molecular and Cellular Engineering, Sam Higginbottom University of Agriculture, Technology and Sciences, Allahabad, India -211007, Department of Skin and STD, Vardhman Mahavir Medical College, Safdarjung Hospital, New Delhi, Department of Skin and STD, Vardhman Mahavir Medical College, Safdarjung Hospital, New Delhi, Biomedical Informatics Centre, National Institute of Pathology – Indian Council of Medical Research, New Delhi, Department of Molecular and Cellular Engineering, Sam Higginbottom University of Agriculture, Technology and Sciences, Allahabad, India -211007



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