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Serum Vitamin D Levels in Children with Immune Thrombocytopenia

[ Vol. 20 , Issue. 2 ]

Author(s):

Giuseppe Lassandro, Francesco Carriero, Viviana Palmieri, Valentina Palladino, Anna Amoruso, Maria Filomena Gallone, Giovanni C. Del Vecchio, Silvio Tafuri, Giovanna Russo, Federica Valente and Paola Giordano*   Pages 221 - 226 ( 6 )

Abstract:


Objective: Immune thrombocytopenia (ITP) is an acquired immuno-mediated disorder characterized by thrombocytopenia with an increased risk of bleeding. In recent years 1,25[OH]2D3 has been rediscovered as an immune modulator. We decided to evaluate serum Vitamin D levels in a cohort of children with immune thrombocytopenia in order to discover if Vitamin D concentrations may predict ITP duration.

Methods: Thirty children were enrolled in this study (sixteen with chronic ITP and fourteen with newly diagnosed ITP) to assess serum Vitamin D levels.

Results: The results showed that 80% of the enrolled children presented a D hypovitaminosis status. Children with newly diagnosis ITP showed no statistically significantly higher median values of Vitamin D compared to chronic ITP.

Conclusion: This study may suggest that Vitamin D deficiency does not represent a chronicity factor for ITP. However, further studies are needed to understand the role of Vitamin D in ITP pathogenesis.

Keywords:

Autoimmunity, children, D vitamin, immune thrombocytopenia, platelets, chronicity.

Affiliation:

Department of Biomedical Science and Human Oncology, Pediatric Unit, University of Bari “Aldo Moro”, Bari, Department of Biomedical Science and Human Oncology, Pediatric Unit, University of Bari “Aldo Moro”, Bari, Department of Biomedical Science and Human Oncology, Pediatric Unit, University of Bari “Aldo Moro”, Bari, Department of Biomedical Science and Human Oncology, Pediatric Unit, University of Bari “Aldo Moro”, Bari, Department of Biomedical Science and Human Oncology, Pediatric Unit, University of Bari “Aldo Moro”, Bari, Department of Biomedical Science and Human Oncology, Hygiene Unit, University of Bari “Aldo Moro”, Bari, Department of Biomedical Science and Human Oncology, Pediatric Unit, University of Bari “Aldo Moro”, Bari, Department of Biomedical Science and Human Oncology, Hygiene Unit, University of Bari “Aldo Moro”, Bari, Pediatric Hematology and Oncology Unit, Azienda Policlinico-Vittorio Emanuele University of Catania, Catania, Department of Biomedical Science and Human Oncology, Pediatric Unit, University of Bari “Aldo Moro”, Bari, Department of Biomedical Science and Human Oncology, Pediatric Unit, University of Bari “Aldo Moro”, Bari

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