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Metabolic Imbalance and Vitamin D Deficiency in Type 1 Diabetes in the Algerian Population

[ Vol. 19 , Issue. 8 ]

Author(s):

Esma Mihoubi, Rachida Raache*, Habiba Amroun, Malha Azzouz, Assia Galleze, Nesrine Zaabat, Abdelghani Aissou, Amina Ferhat, Hassiba Guettaf-Sadi, Amel Boutemeur, Zoulikha Aoudia, Aissa Boudiba, Chafia Touil-Boukoffa, Mohamed C. Abbadi and Nabila Attal   Pages 1172 - 1176 ( 5 )

Abstract:


Background: We aimed to assess Vitamin D levels in patients with Type 1 Diabetes (T1D) and to investigate the correlation between vitamin D and metabolic imbalance.

Material and Methods: For our study, we selected thirty-one patients with T1D without complications and fifty-seven healthy controls. Diabetic patients were diagnosed using the criteria of the World Health Organization/American Diabetes Association. Vitamin D, Parathyroid Hormone (PTH), insulin and C peptide assay were performed using chimilunescence. Glucose level, lipid profile, glycated haemoglobin (HbA1c) and ionogram were also analysed.

Results: Vitamin D, HbA1c and Gly levels were found to be significant in T1D patients than in controls (P<0.5). However, for PTH, no significant difference was observed (P > 0. 05) and the results show a non-significant difference of total cholesterol potassium, sodium, phosphor and calcium concentration averages.

Conclusion: Our results indicate that the deficiency of VD is associated with an increased risk of T1DM in Algerian population.

Keywords:

Diabetes Type 1 (DT1), Parathyroid Hormone (PTH), Vitamin D, glycemic level, modulation, HbA1c.

Affiliation:

Laboratory of Cellular and Molecular Biology, Cytokine and NO Synthases. University of Science and Technology, Houari Boumediene (USTHB), Algiers, Laboratory of Cellular and Molecular Biology, Cytokine and NO Synthases. University of Science and Technology, Houari Boumediene (USTHB), Algiers, Central Laboratory, Parnet Hospital, Algiers, Diabetology Department of Mustapha Pacha Hospital, Algiers, Laboratory of Cellular and Molecular Biology, Cytokine and NO Synthases. University of Science and Technology, Houari Boumediene (USTHB), Algiers, Immunology Department, Pasteur Institute of Algiers, Immunology Department, Pasteur Institute of Algiers, University of Boumerdes, Faculty of Biology, Algeries, University of Boumerdes, Faculty of Biology, Algeries, University of Boumerdes, Faculty of Biology, Algeries, University of Boumerdes, Faculty of Biology, Algeries, Diabetology Department of Mustapha Pacha Hospital, Algiers, Laboratory of Cellular and Molecular Biology, Cytokine and NO Synthases. University of Science and Technology, Houari Boumediene (USTHB), Algiers, Immunology Department, Pasteur Institute of Algiers, Immunology Department, Pasteur Institute of Algiers

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