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The Association between Dyslipidemia and Preterm Birth: A Prospective Cohort Study in The North of Iran

[ Vol. 20 , Issue. 2 ]

Author(s):

Seyedeh H. Sharami, Mahboobeh Gholipour, Forozan Milani, Ehsan Kazemnejad, Seyedeh F.D. Heirati and Zahra A. Ranjbar*   Pages 227 - 233 ( 7 )

Abstract:


Background: Dyslipidemia is recognized as an important factor in the incidence of Preterm Birth (PTB). The early diagnosis of factors affecting PTB is important in the reduction of maternalneonatal complications; therefore, we aimed to evaluate the association between dyslipidemia and PTB in women from the Guilan province of Iran.

Methods: The current investigation was a prospective cohort study on 378 pregnant women in Rasht city (Guilan province), during 2018-2019. Samples were randomly selected among pregnant women who referred to Al-Zahra hospital. Association of the lipid profiles: Total Cholesterol (TC), High- Density Lipoprotein (HDLC), Low-Density Lipoprotein (LDLC), and Triglycerides (TG) with PTB was assessed using the Chi-square, Fisher tests and logistic regression analysis.

Results: Our findings showed that of the evaluated lipid profiles, TG and TC had the highest predictive power with AUC =0.833 (95٪, CI: 0.736-0.930) and 0.772 (95%, CI: 0.676-0.867), respectively; also, their sensitivity and specificity were 83.3%, 70.2% and 83.3%, 66.1%, respectively. Moreover, abnormal LDL concentrations increase the risk of PTB by two folds (P < 0.05).

Conclusion: It seems that by controlling the lipid profiles of pregnant women, the risk of PTB could be reduced.

Keywords:

Dyslipidemia, preterm birth, women, pregnancy, triglycerides, Iran, prospective cohort study.

Affiliation:

Department of Obstetrics & Gynecology, Reproductive Health Research Center, Azzhra Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Department of Cardiology, Cardiovascular Diseases Research Center, Heshmat Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Department of Obstetrics & Gynecology, Reproductive Health Research Center, Azzhra Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Department of Biostatictis, School of Medicine, Guilan University of Medical Sciences, Rasht, Department of Obstetrics & Gynecology, Reproductive Health Research Center, Azzhra Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Department of Endocrinology and Metabolism, Reproductive Health Research center, Guilan University of Medical Sciences, Rasht

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