Submit Manuscript  

Article Details


Metformin: Up to Date

[ Vol. 20 , Issue. 2 ]

Author(s):

Silvia Sciannimanico, Franco Grimaldi, Fabio Vescini, Giovanni De Pergola , Massimo Iacoviello, Brunella Licchelli , Edoardo Guastamacchia , Vito A. Giagulli and Vincenzo Triggiani *   Pages 172 - 181 ( 10 )

Abstract:


Background: Metformin is an oral hypoglycemic agent extensively used as first-line therapy for type 2 diabetes. It improves hyperglycemia by suppressing hepatic glucose production and increasing glucose uptake in muscles. Metformin improves insulin sensitivity and shows a beneficial effect on weight control. Besides its metabolic positive effects, Metformin has direct effects on inflammation and can have immunomodulatory and antineoplastic properties.

Aim: The aim of this narrative review was to summarize the up-to-date evidence from the current literature about the metabolic and non-metabolic effects of Metformin.

Methods: We reviewed the current literature dealing with different effects and properties of Metformin and current recommendations about the use of this drug. We identified keywords and MeSH terms in Pubmed and the terms Metformin and type 2 diabetes, type 1 diabetes, pregnancy, heart failure, PCOS, etc, were searched, selecting only significant original articles and review in English, in particular of the last five years.

Conclusion: Even if many new effective hypoglycemic agents have been launched in the market in the last few years, Metformin would always keep a place in the treatment of type 2 diabetes and its comorbidities because of its multiple positive effects and low cost.

Keywords:

Metformin, type 2 diabetes, type 1 diabetes, insulin resistance, polycystic ovary syndrome, heart failure.

Affiliation:

Endocrinology and Metabolism Unit, University Hospital of Udine, Udine, Endocrinology and Metabolism Unit, University Hospital of Udine, Udine, Endocrinology and Metabolism Unit, University Hospital of Udine, Udine, Clinical Nutrition Unit, Medical Oncology, Department of Biomedical Science and Human Oncology, University of Bari “Aldo Moro”, School of Medicine, Bari, University Cardiology Unit, Cardiothoracic Department, Policlinic University Hospital, Bari, Interdisciplinary Department of Medicine, Section of Internal Medicine, Geriatrics, Endocrinology and Rare Diseases, University of Bari “Aldo Moro”, School of Medicine, Bari, Interdisciplinary Department of Medicine, Section of Internal Medicine, Geriatrics, Endocrinology and Rare Diseases, University of Bari “Aldo Moro”, School of Medicine, Bari, Interdisciplinary Department of Medicine, Section of Internal Medicine, Geriatrics, Endocrinology and Rare Diseases, University of Bari “Aldo Moro”, School of Medicine, Bari, Interdisciplinary Department of Medicine, Section of Internal Medicine, Geriatrics, Endocrinology and Rare Diseases, University of Bari “Aldo Moro”, School of Medicine, Bari

Graphical Abstract:



Read Full-Text article