Submit Manuscript  

Article Details


The Neuromodulatory Effects of ω-3 Fatty Acids and Nano-Curcumin on the COX-2/ iNOS Network in Migraines: A Clinical Trial Study from Gene Expression to Clinical Symptoms

[ Vol. 19 , Issue. 6 ]

Author(s):

Mina Abdolahi, Arash Jafarieh, Payam Sarraf , Mohsen Sedighiyan , Abolghasem Yousefi , Abbas Tafakhori, Hamed Abdollahi , Farahnaz Salehinia and Mahmoud Djalali *   Pages 874 - 884 ( 11 )

Abstract:


Background: Migraine is a common neuroinflammatory disorder characterized by recurrent attacks of pain. Human and experimental models of migraine studies have demonstrated the role played by COX-2/ iNOS in migraine’s neuroinflammatory pathogenesis. COX-2 and iNOS are closely linked and both contribute to inflammation and neurogenic pain in the central nervous system. Omega- 3 fatty acids and curcumin, an active polyphenol of turmeric, have anti-inflammatory and neuroprotective effects through several mechanisms, including the suppression of COX-2 and iNOS gene expression, as well as their serum levels. The aim of the present study is to evaluate the nutrigenomic effects of ω-3 fatty acids, nano-curcumin, and a combination of the two, on neuroinflammation and clinical symptoms in migraine patients.

Methods: This study reports the results of a clinical trial over a 2-month period, involving 74 episodic migraine patients who received ω-3 fatty acids, nano-curcumin, a combination of them, or a placebo. At the start and end of the study, the expression of COX-2/iNOS (in peripheral mononuclear blood cells isolated from patients) and COX-2/iNOS serum levels were measured, using real-time PCR and ELISA respectively. The frequency, severity and duration of pain attacks were also recorded.

Results: The results of the present trial showed that ω-3 fatty acids and nano-curcumin can reinforce each other’s effects in the downregulation of COX-2/iNOS mRNA, as well as reduce their serum levels. In addition, the combination of ω-3 and nano-curcumin significantly reduced the frequency, severity and duration of headaches (P<0.05).

Conclusion: These findings indicate that combination therapy of ω-3 fatty acids and nano-curcumin can be considered as a promising new approach in migraine prevention.

Keywords:

Migraine, curcumin, ω-3 fatty acids, COX-2, iNOS, headache.

Affiliation:

AmirAlam Hospital Complex, Tehran University of Medical Sciences, Tehran, AmirAlam Hospital Complex, Tehran University of Medical Sciences, Tehran, Department of Neurology, Iranian Centre of Neurological Research, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, AmirAlam Hospital Complex, Tehran University of Medical Sciences, Tehran, Iranian Centre of Neurological Research, Neurosciences Institute, Tehran University of Medical Sciences, Tehran, AmirAlam Hospital Complex, Tehran University of Medical Sciences, Tehran, AmirAlam Hospital Complex, Tehran University of Medical Sciences, Tehran, Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran



Read Full-Text article