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Multi-Target Drugs Against Metabolic Disorders

[ Vol. 19 , Issue. 4 ]

Author(s):

Luciana Scotti*, Alex France Messias Monteiro, Jéssika de Oliveira Viana, Francisco Jaime Bezerra Mendonça, Hamilton M. Ishiki, Ernestine Nkwengoua Tchouboun, Rodrigo Santos and Marcus Tullius Scotti   Pages 402 - 418 ( 17 )

Abstract:


Background: Metabolic disorders are a major cause of illness and death worldwide. Metabolism is the process by which the body makes energy from proteins, carbohydrates, and fats; chemically breaking these down in the digestive system towards sugars and acids which constitute the human body's fuel for immediate use, or to store in body tissues, such as the liver, muscles, and body fat.

Objective: The efficiency of treatments for multifactor diseases has not been proved. It is accepted that to manage multifactor diseases, simultaneous modulation of multiple targets is required leading to the development of new strategies for discovery and development of drugs against metabolic disorders.

Method: In silico studies are increasingly being applied by researchers due to reductions in time and costs for new prototype synthesis; obtaining substances that present better therapeutic profiles.

Discussion: In the present work, in addition to discussing multi-target drug discovery and the contributions of in silico studies to rational bioactive planning against metabolic disorders such as diabetes and obesity, we review various in silico study contributions to the fight against human metabolic pathologies.

Conclusion: In this review, we have presented various studies involved in the treatment of metabolic disorders; attempting to obtain hybrid molecules with pharmacological activity against various targets and expanding biological activity by using different mechanisms of action to treat a single pathology.

Keywords:

Docking, multi-target drugs, polypharmacology, metabolic disorders, diabetes, obesity.

Affiliation:

Teaching and Research Management - University Hospital, Federal University of Paraíba, João Pessoa – PB Pessoa – PB, Brazil., Postgraduate Program in Natural and Synthetic Bioactive Products, Federal University of Paraíba, João Pessoa – PB, Postgraduate Program in Natural and Synthetic Bioactive Products, Federal University of Paraíba, João Pessoa – PB, Postgraduate Program in Natural and Synthetic Bioactive Products, Federal University of Paraíba, João Pessoa – PB, University of Western São Paulo (Unoeste), Presidente Prudente, SP, Department of Organic Chemistry, Faculty of Science, University of Yaounde IPO Box 812, Yaounde-Cameroo, Laboratory of Synthesis and Drug Delivery, Department of Biological Science, State University of Paraiba, João Pessoa, PB, Postgraduate Program in Natural and Synthetic Bioactive Products, Federal University of Paraíba, João Pessoa – PB



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