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Comparing Allergist and Cardiologist Considerations for the Optimal Management of Thienopyridines Hypersensitivity

[ Vol. 19 , Issue. 1 ]


Gianfanco Calogiuri*, Alessandro Mandurino-Mirizzi, Claudio Parlangeli, Luigi Macchia, Caterina Foti and Michael P. Savage   Pages 2 - 12 ( 11 )


Background and Objective: The thienopyridine family includes ticlopidine, clopidogrel and prasugrel which are antiplatelet drugs largely used, mainly associated to aspirin, for treatment of acute coronary syndromes and after percutaneous coronary interventions, to avoid thrombosis. In some patients, thienpyridines may cause hypersensitivity reactions which jeopardize the optimal therapeutic and preventive approach to vascular diseases. The management of thienopyridine hypersensitivity seems to be best done as an interdisciplinary collaboration between the allergist and cardiologist.

Method: The present study investigates the management of thienopyridines hypersensitivity on the basis of published case reports and studies, comparing the pro and contro of pharmacological treatments, different desensitization protocols to thienopyridines and substitution of antiplatelet agents eaches others, according to the point of view of cardiologist and allergist. For the cardiologist, the important issues are the necessity of continuing therapy, the desired duration of therapy based on the clinical indication of the individual patient and appropriateness of using one of the alternative P2Y12 inhibitors. For the allergist, the important issues are weighing the risk and benefits of the various therapeutic options: treating “through” desensitization, or switching to an alternative agent.

Results and Conclusion: All the data seem to suggest that only working together, a cardio-allergy team of specialists may evaluate and offer the best approach to clinical decision-making for the individual patient.


Thienopyridines, hypersensitivity, ticlopidine, clopidogrel, prasugrel, ticagrelor desensitization, premedication.


Department of Emergency and Organ Transplantation, School of Allergology and Clinical Immunology, University of Bari Aldo Moro, Bari, Cardiology Department - University of Pavia, Fondazione IRCCS Policlinico San Matteo, Pavia, Cardiology Intensive Care Unit – Civil Hospital San Giuseppe da Copertino - Copertino Lecce, Department of Emergency and Organ Transplantation, School of Allergology and Clinical Immunology, University of Bari Aldo Moro, Bari, Department of Biomedical Science and Human Oncology, Dermatological Clinic, University of Bari, 70124 Bari, Department of Medicine, Jefferson Angioplasty Center, Thomas Jefferson University Hospital, Philadelphia

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