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Variation at Interleukin-10 Locus Represents Susceptibility to Psoriasis in North Indian Population

[ Vol. 19 , Issue. 1 ]

Author(s):

Wani Aadil, Rajinder Kaur*, Bashir Ahmad Ganai, Tahseena Akhtar, Tarun Narang, Iffat Hassan and Sunil Kumar   Pages 53 - 58 ( 6 )

Abstract:


Background: IL-10 is an important pleiotropic, immunoregulatory and anti-inflammatory cytokine which plays a significant role in the pathogenesis of psoriasis.

Objective: The aim of the present study was to determine whether the three polymorphic sites of the IL-10 gene, haplotype and serum level confer susceptibility to psoriasis.

Method: 200 psoriatic patients and 200 controls were genotyped for three IL-10 polymorphic sites by ARMS polymerase chain reaction. Serum levels of IL -10 were measured by ELISA.

Results: Our results demonstrated that polymorphism of IL-10 -592 C/A (adjusted* OR = 9.25; 95% CI =3.16- 27.06) and IL-10 1082 A/G (adjusted* OR = 4.28; (95% CI =1.46- 12.56) was found to be in association with increased risk of psoriasis while as IL- 10 819 C/T (adjusted* OR= 1.60; (95% CI = 0.65-3.95) polymorphism does not show any significant association with the risk of psoriasis. HT7 GTC haplotype is associated with increased risk of psoriasis. Serum levels of IL-10 were found to be significantly low in patients, as compared to controls with a non-significant correlation between serum IL-10 level and psoriasis severity.

Conclusion: IL-10 polymorphism imparted significant risk towards the development of psoriasis in North Indian population. Highlighting the role of IL-10 cytokine in the pathogenesis of psoriasis will help in the development of psoriasis management.

Keywords:

Psoriasis, IL-10 polymorphism, ARMS PCR, ELISA, pleiotropic, cytokine.

Affiliation:

Department of Human Genetics, Punjabi University, Patiala, Punjab, Department of Human Genetics, Punjabi University, Patiala, Punjab, Centre of Research and Development (CORD) University of Kashmir Srinagar, Jammu and Kashmir, Department of Human Genetics, Punjabi University, Patiala, Punjab, Department of Dermatology, Venerology and Leprology Post Graduate Institute of Medical Education and Research Chandigarh, Chandigarh, Department of Dermatology, Venerology and Leprology SMHS Srinagar, Srinagar, Jammu and Kashmir, Department of Human Genetics, Punjabi University, Patiala, Punjab

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