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Eyelid Dermatitis and Contact Sensitization to Nickel: Results from an Italian Multi-Centric Observational Study

[ Vol. 19 , Issue. 1 ]

Author(s):

Alessandro Borghi*, Monica Corazza, Elisa Maietti, Cataldo Patruno, Maddalena Napolitano, Donatella Schena, Maria Letizia Musumeci, Giuseppe Micali, Thea Magrone, Paolo Romita and Caterina Foti   Pages 38 - 45 ( 8 )

Abstract:


Background: Due to the sensitizing constituents of eye cosmetics, allergic contact dermatitis is considered a frequent cause of eyelid dermatitis. An association between eyelid dermatitis and nickel contained in make-ups remains controversial.

Objective: The study aimed to assess the association between nickel allergy, the use of pigmented makeup products and self-reported eyelid dermatitis.

Method: This multi-centric, cross-sectional study enrolled 165 women sensitized to nickel (patients) and 103 women without intolerance to metals (controls). We recorded: demographics, atopy, use of pigmented eye cosmetics (mascara, eyeshadow, eyeliner, eyebrow pencil), and previous eyelid dermatitis. Among the patients, any co-sensitization to cosmetics or metals was recorded.

Results: 87.3% of the patients and 91.3% of the controls reported their use of eye make-up; 44.9% and 52.4%, respectively, reported previous episodes of eyelid dermatitis, without significant differences. The occurrence of eyelid dermatitis was significantly associated with the use of eye make-up products, both in general and considering each product separately. Age, atopy, or co-sensitization to other metals or cosmetics did not affect the occurrence of eyelid dermatitis.

Conclusion: Nickel allergy should not be considered the main risk factor for eyelid dermatitis. The use of pigmented eye make-up may be a triggering factor for eyelid dermatitis, probably due to an irritant action.

Keywords:

Eyelid dermatitis, nickel allergy, make-up products, allergic contact dermatitis, cosmetics, irritant contact dermatitis.

Affiliation:

Department of Medical Sciences, Section of Dermatology and Infectious Diseases, University of Ferrara, Ferrara, Department of Medical Sciences, Section of Dermatology and Infectious Diseases, University of Ferrara, Ferrara, Department of Medical Sciences, University of Ferrara, Center for Clinical Epidemiology, Ferrara, Department of Clinical Medicine and Surgery, Section of Dermatology, University of Naples Federico II, Naples, Section of Dermatology, Department of Medicine and Heath Science Vincenzo Tiberio, University of Molise, Campobasso, Section of Dermatology and Venereology, Department of Medicine, University of Verona, Verona, Dermatology Clinic, University of Catania, A.O.U. Policlinico-Vittorio Emanuele, Catania, Dermatology Clinic, University of Catania, A.O.U. Policlinico-Vittorio Emanuele, Catania, Department of Basic Medical Sciences, Neuroscience and Sensory Organs, University of Bari, School of Medicine, Bari, Department of Biomedical Science and Human Oncology, Dermatological Clinic, University of Bari, Bari, Department of Biomedical Science and Human Oncology, Dermatological Clinic, University of Bari, Bari

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