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Lower Urinary Tract Symptoms in Metabolic Syndrome in Young Adults

[ Vol. 18 , Issue. 3 ]

Author(s):

Svetlana I. Kseneva*, Zakhar A. Yurmazov, Maksim S. Timofeev, Elena V. Borodulina and Vladimir V. Udut   Pages 230 - 234 ( 5 )

Abstract:


Background and Objective: Metabolic syndrome (MS) is widespread among middle age people and presents an acute issue in preventive cardiology. A list of conditions associated with MS is quite long and it is constantly growing. Despite the data, described in scientific literature, on general pathogenetic mechanisms, the conditions associated with androgynous status, are not included into the register of MS associated nosologies. Such association is identified in men older than 60 years old and is explained by age related hypoandrogenaemia. However, the issue of occurrence rate of lower urinary tract syndromes (LUTS) in young men with MS and their association of androgen levels remains open.

Methods: 62 European men aged from 25 to 40 (30 patients with MS and 32 conditionally healthy persons) were examined. Apart from generally accepted methods of physical and instrumental examination, evaluation of hormonal status (insulin, testosterone, dehydrotestosteron), IPSS-QOI testing and transrectal USI of prostate and bladder were performed.

Results: Revealed a high frequency of increasing the size and volume of the prostate gland, the number of points on the IPSS questionnaire, corresponding to the initial manifestation of hyperplastic prostate diseases on the background of insulin resistance and normal androgen levels raises questions about the search for new pathogenetic links of the metabolic syndrome with the processes of induction of prostate growth.

Conclusion: Modern standards of examination of patients with MS do not include routine methods for the detection of prostate diseases. The above data raise questions about the need for further study in young patients with verified MS, including IPSS-QOI questionnaire surveying and TRUS.

Keywords:

Metabolic syndrome, prostate, androgens, insulin resistance, LUTS, obesity.

Affiliation:

Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences. 634028, 3 Lenina Ave., Tomsk, Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences. 634009, 5 Cooperative Str., Tomsk, Department of Clinical Laboratory Diagnostics at the Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, 634028, 3 Lenina Ave., Tomsk, Department of Therapeutic Drug Monitoring at the Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences. 634028, 3 Lenina Ave., Tomsk, Russian Academy of Sciences, Scientific and Clinical Works at the Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences. 634028, 3 Lenina Ave., Tomsk

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