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Relationship between Proinflammatory Cytokines/Chemokines and Adipokines in Serum of Young Adults with Obesity

[ Vol. 18 , Issue. 3 ]

Author(s):

Maraisa D. Borges, Eduardo L. Franca, Mahmi Fujimori, Silvia M.C. Silva, Patricia G.F. de Marchi, Alessandra L. Deluque, Adenilda C. Honorio-Franca* and Luiz C. de Abreu   Pages 260 - 267 ( 8 )

Abstract:


Background and Objective: The adipose tissue has been recognized as an important endocrine organ, which is metabolically active and expresses and secretes various inflammatory cytokines. Inflammation is involved in obesity-related complications. As such, the present study investigated the correlation between biochemical parameters, serum proinflammatory cytokines and adipokines in individuals with obesity.

Methods: Based on the body mass index (BMI), 30 subjects were divided into 3 groups: eutrophic (GC, n = 10), overweight (GOW, n = 10) and obese (GOB, n = 10). Serum glucose, cholesterol (total-C, HDLC and LDL-C), triglycerides, total proteins, uric acid and insulin were determined, as well as cytokines IL-8, TNF-α, IL-1β, and IL-6, leptin and adiponectin.

Results: GOB showed the highest glucose, total and LDL-C, triglycerides, uric acid, insulin, leptin, IL- 8, IL-1β, IL-6, TNF-α and lowest adiponectin levels. In general, adiponectin exhibited an inverse correlation with BMI, abdominal circumference, LDL-C, IL-6, TNF-α, leptin and leptin-adiponectin ratio (LAR) and a positive correlation with HDL-C. Leptin was positively correlated with BMI, abdominal circumference, insulin, IL-6, TNF-α and LAR and negatively correlated with HDL-C and adiponectin. The LAR was positively correlated with BMI, waist circumference, insulin, TNF-α and negatively associated with HDL-C.

Conclusion: The results confirm that obesity changes the lipid and glycemic profiles of individuals, increases the proinflammatory adipokine levels and reduces those of anti-inflammatory adipokines, promoting a state of chronic inflammation.

Keywords:

Obesity, adipokine, inflammation, dyslipidemia, cytokine, serum.

Affiliation:

Laboratory of Scientific Writing, Department of Morphology and Physiology, School of Medicine of ABC, Santo Andre, SP, Institute of Biological and Health Science - Federal University of Mato Grosso – Barra do Garcas – MT, Institute of Biological and Health Science - Federal University of Mato Grosso – Barra do Garcas – MT, Institute of Biological and Health Science - Federal University of Mato Grosso – Barra do Garcas – MT, Institute of Biological and Health Science - Federal University of Mato Grosso – Barra do Garcas – MT, Institute of Biological and Health Science - Federal University of Mato Grosso – Barra do Garcas – MT, Institute of Biological and Health Science - Federal University of Mato Grosso – Barra do Garcas – MT, Laboratory of Scientific Writing, Department of Morphology and Physiology, School of Medicine of ABC, Santo Andre, SP

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