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Ankylosing Spondylitis Among Familial Mediterranean Fever Patients

[ Vol. 18 , Issue. 2 ]


Mira Merashli, Mohammad Hassan A. Noureldine, Yehia Tfayli, Ali Jawad and Imad Uthman*   Pages 148 - 154 ( 7 )


Background: Familial Mediterranean Fever (FMF) is one of the most common hereditary auto-inflammatory diseases especially among Arabs, Armenians, Jews, and Turks characterized by recurrent attacks of fever, abdominal pain and arthritis.Whether the prevalence of ankylosing spondylitis (AS) is increased in FMF patients is a matter of debate. This review will summarize all the literature data relevant to this topic.

Methods: We searched all the articles through PubMed and Embase databases from 1963 until 2017 addressing the relationship between AS and FMF patients.

Results: The prevalence of AS among FMF patients is highly variable. However, a significant relationship was found to exist between MEFV gene mutations and AS. Most patients with coexistent MEFV gene mutations and AS were human leucocyte antigen B27 (HLA-B27) negative. The effect of these mutations on AS severity and prognosis was not significant.

Conclusion: Large based population studies are needed to further assess the existence of MEFV gene mutations among AS patients and their effect on the clinical course of the disease in addition to assessment of AS prevalence in patients with FMF.


Familial mediterranean fever, ankylosing spondylitis, MEFV, HLA-B27, spondyloarthritis, spondyloarhtopathy, sacroiliitis.


Department of Internal Medicine, Division of Rheumatology, American University of Beirut, Beirut, Department of Neurosurgery, Gilbert and Rose-Marie Chagoury School of Medicine, Lebanese American University, Beirut, Department of Surgery, Division of Orthopedic Surgery, American University of Beirut, Beirut, Department of Rheumatology, The Royal London Hospital, Bancroft Road, London E1 4DG, Department of Internal Medicine, Division of Rheumatology, American University of Beirut, Beirut

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