Article Details


Food Protein Induced Proctocolitis: A Benign Condition with an Obscure Immunologic Mechanism

[ Vol. 17 , Issue. 1 ]

Author(s):

Sophia Tsabouri, Nicolaos Nicolaou, Konstantinos Douros, Athina Papadopoulou and Kostas N. Priftis   Pages 32 - 37 ( 6 )

Abstract:


Food protein-induced proctocolitis (FPIP) is the most common colonic manifestation of food allergy in infants, accounting for up to 60% of exclusively breast-fed children. The causative foods derived from the mother’s diet, which are then excreted in her milk. The suggested risk factors for the development of FPIP are an immature immune system, altered intestinal permeability and other factors that activate local immune function, such as genetic susceptibility in combination with particularly sensitizing foods. FPIP is an enhanced immune responsiveness of some infants to very small amounts of food antigens, inducing an inflammatory mucosal response, mediated by T cells.

Keywords:

Breast feeding, food allergy, infants, immunologic response, intolerance, allergic proctocolitis.

Affiliation:

Department of Paediatrics, Child Health Department, University of Ioannina School of Medicine, Ioannina, Greece. Stavrou Niarxou Av, Ioannina, 45500, University of Manchester, University Hospital of South Manchester NHS Foundation Trust, Manchester M23 9LT, Paediatric Allergy and Pulmonology Units Third Department of Paediatrics, School of Medicine, National and Kapodistrian University of Athens, University General Hospital "Attikon", Athens, Pediatric Allergy and Asthma Unit, KAT General Hospital, Athens, Paediatric Allergy and Pulmonology Units Third Department of Paediatrics, School of Medicine, National and Kapodistrian University of Athens, University General Hospital "Attikon", Athens

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